Blockade of cyclooxygenase by NSAIDs leads to increased production of which mediators?

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Multiple Choice

Blockade of cyclooxygenase by NSAIDs leads to increased production of which mediators?

Explanation:
Blocking cyclooxygenase stops arachidonic acid from being converted to prostaglandins and thromboxanes. With this pathway blocked, more arachidonic acid is available for the lipoxygenase route, boosting leukotriene production. Leukotrienes are potent mediators that promote bronchoconstriction and inflammation, so their synthesis increases when COX is inhibited. Histamine and bradykinin come from different systems and aren’t driven up by COX blockade, and prostaglandin production actually falls.

Blocking cyclooxygenase stops arachidonic acid from being converted to prostaglandins and thromboxanes. With this pathway blocked, more arachidonic acid is available for the lipoxygenase route, boosting leukotriene production. Leukotrienes are potent mediators that promote bronchoconstriction and inflammation, so their synthesis increases when COX is inhibited. Histamine and bradykinin come from different systems and aren’t driven up by COX blockade, and prostaglandin production actually falls.

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