Owl eye intranuclear inclusions are characteristic of which virus?

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Multiple Choice

Owl eye intranuclear inclusions are characteristic of which virus?

Explanation:
Owl eye intranuclear inclusions are a hallmark of cytomegalovirus infection. These are large cells with prominent basophilic inclusion bodies inside the nucleus, often surrounded by a clear halo, giving an “owl’s eye” appearance. This histologic pattern occurs because CMV replicates in the nucleus and produces characteristic intranuclear inclusions, making it a distinctive clue on tissue samples. The other organisms listed do not produce this nuclear inclusion pattern: Mycoplasma and Klebsiella are bacterial pathogens with different tissue changes, and RSV tends to cause cytoplasmic inclusions and syncytia rather than intranuclear owl-eye inclusions.

Owl eye intranuclear inclusions are a hallmark of cytomegalovirus infection. These are large cells with prominent basophilic inclusion bodies inside the nucleus, often surrounded by a clear halo, giving an “owl’s eye” appearance. This histologic pattern occurs because CMV replicates in the nucleus and produces characteristic intranuclear inclusions, making it a distinctive clue on tissue samples. The other organisms listed do not produce this nuclear inclusion pattern: Mycoplasma and Klebsiella are bacterial pathogens with different tissue changes, and RSV tends to cause cytoplasmic inclusions and syncytia rather than intranuclear owl-eye inclusions.

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