Panacinar emphysema is associated with which condition?

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Multiple Choice

Panacinar emphysema is associated with which condition?

This item tests the link between a lung condition pattern and a genetic deficiency of a protective enzyme. Panacinar emphysema is classically seen with alpha-1 antitrypsin deficiency, a genetic disorder where the liver makes an abnormal protein that can accumulate in the liver and cause liver disease. The lack of enough alpha-1 antitrypsin means neutrophil elastase can destroy elastin in the walls of the alveoli throughout the acinus, producing uniform destruction characteristic of panacinar emphysema. So the same defect that harms the lungs also causes liver disease due to the abnormal protein accumulating in hepatocytes. The other diseases listed aren’t the typical associated conditions with this emphysema pattern.

This item tests the link between a lung condition pattern and a genetic deficiency of a protective enzyme. Panacinar emphysema is classically seen with alpha-1 antitrypsin deficiency, a genetic disorder where the liver makes an abnormal protein that can accumulate in the liver and cause liver disease. The lack of enough alpha-1 antitrypsin means neutrophil elastase can destroy elastin in the walls of the alveoli throughout the acinus, producing uniform destruction characteristic of panacinar emphysema. So the same defect that harms the lungs also causes liver disease due to the abnormal protein accumulating in hepatocytes. The other diseases listed aren’t the typical associated conditions with this emphysema pattern.

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